Non-Alcoholic Steatohepatitis (NASH) Clinical Trials

Non-Alcoholic Fatty Liver Disease (NAFLD) & Non-Alcoholic Steatohepatitis (NASH)

Non-alcoholic steatohepatitis (NASH) is a silent disease that develops from non-alcoholic fatty liver disease (NAFLD), a condition in which excess fat builds up in your liver. It is not caused by heavy alcohol use. People with NASH develop liver inflammation which may cause scarring and further damage including cirrhosis and liver failure. NAFLD affects about 80 – 100 million people in the United States and is the most common cause of chronic liver disease.

Both NAFLD and NASH have few, or no symptoms. If you do have symptoms, you may feel tired or have discomfort in the upper right side of your abdomen. When a person has fatty liver disease, blood tests may not show elevated liver enzymes and may go undiagnosed for many years, eventually progressing to NASH. With NASH, liver enzymes are elevated in about 90% of cases, but a definitive diagnosis requires a liver biopsy.

Have you been diagnosed with NASH or NAFLD?

If so, click below to find a currently enrolling study.

Though the exact cause of NASH is unknown, it is seen more frequently in people with certain medical conditions. The prevalence of NASH continues to rise with the ongoing obesity and diabetes epidemic. Over the next decade, it is projected to become the leading indication for liver transplant, surpassing chronic hepatitis C and alcoholic liver disease. Despite its growing numbers, the NASH patient population remains underdiagnosed. Currently, there are no approved drugs for the treatment of NASH on the market, and the FDA is supporting efforts to discover effective treatments for this disease.

The causes of NAFLD and NASH are still being studied but research suggests that certain health conditions make you more likely to develop these conditions.

Potential causes of NAFLD:

  • Obesity and being overweight
  • Insulin resistance
  • High cholesterol and/or high triglycerides
  • Metabolic syndrome
  • Type 2 diabetes
  • Genetics

Potential causes of NASH:

  • Obesity, with a larger waist size
  • High blood pressure
  • High cholesterol and/or high triglycerides
  • Metabolic syndrome
  • Type 2 diabetes

Additionally, there are some less common causes of NAFLD and NASH that include rapid weight loss, hepatitis C, and certain medications.

Do you think you may have NASH or NAFLD?

If you suspect you may have NASH or NAFLD, contact your physician today.

You can learn more about NASH and NAFLD here:


Any Questions?

If you have any questions regarding trial participation, take a moment to read through our Frequently Asked Questions. You may also contact your local trial clinic or call us directly at 336.608.3500.

Contact Us Online
Confidentiality Statement