C-diff

C. Difficile Vaccine Studies

 

PMG Research enrolls vaccine trials throughout North Carolina, South Carolina, Tennessee, Illinois, and Iowa for clostridium difficile, also known as c. difficile or c. diff.  C. diff is a bacterium that can cause severe diarrhea and life-threatening colitis, especially in vulnerable populations. Currently, there is not an FDA-approved vaccine to prevent c. diff infection.  

What is c. diff?

C. diff is a common bacteria that is often present in the digestive tract without causing infection. Pathogenic c. diff bacteria can spread easily and survive outside of the body for long periods of time. The bacteria thrives in the human body, but when the bacteria becomes stressed (such as when it is outside of the body), it creates spores that are extremely resistant to alcohol-based cleaners and routine cleaning. 

Who is at risk for c. diff infection?

C. diff infection can occur in people with compromised gut flora, or a lack of “good” bacteria within the digestive tract, which is most commonly due to antibiotic use. C. diff infection also spreads easily in hospitals or nursing homes, or other places where people are confined in community institutions. Because c. diff is both very common and very resistant to routine cleaning, it can be extremely difficult to eradicate. 

I’ve never had c. diff infection. Can I participate in a vaccine research study?

While all vaccine research studies are different, you do not need to have had c. diff to participate in one of our clinical trials. CLICK HERE to search available c. diff vaccine studies and see if you meet the qualifications to participate.

If c. diff is commonly found in the human body, why does it cause infection?

For most people, naturally occurring c. difficile bacteria is kept in check through a careful balance of bacteria in the gut. Antibiotics harm both good and bad bacteria, creating an environment where the resistant c. diff bacteria can thrive. When this bacteria enters the colon, it can cause severe diarrhea and life threatening inflammation of the colon. 


 

Click to see a list of currently enrolling c. diff vaccine studies

Any Questions?

If you have any questions regarding trial participation, take a moment to read through our Frequently Asked Questions. You may also contact your nearest study center.

Contact Us Online
Flu vaccine clinical trials